MODERNA will test its Omicron booster job on 3,000 people in the UK.
This will be the first major study in the UK to use a vaccine that is not based on the original Wuhan strain of the virus.
Health Secretary Sajid Javed said: “The UK is a world leader when it comes to research and development of vaccines and medicines.
“It’s amazing to see these abilities being put to good use. About 3,000 people are expected to take part in this important clinical trial.
“I urge anyone who is eligible to participate in this important study to play their part in protecting the country for years to come as we are learning to live with the Quaid 19.”
The Moderna trial will test the new job as the third or fourth dose and will be run from 29 hospitals in England, Scotland and Wales.
Healthy volunteers aged 16 and over will be eligible for the trial unless they have a code from November 2021.
They may not have been vaccinated in the last three months, but they must have two doses so that the new job can be used as a third or fourth booster dose.
The US firm redesigned the vaccine after tests showed that real jobs did not provide a good protection against catching Omicron because it had changed so much.
Ministers have planned annual vaccine vaccinations for high-risk people – and the use of foods made for specific types of foods should mean fewer jobs.
Studies have shown that protection against Omicron from existing vaccines begins to decline after a few months, even with booster.
Andrew Styanowski, a professor at the National Institutes of Health Research, said: “We’ve seen from the Omicron variant how some existing vaccines can be less protective against newer variants.
“Continued research into which vaccine combinations work best is essential to help us stay safe.”
This came after UKHSA experts examined a lengthy study of CoVID and found that vaccination reduced the risk of the condition by half.
About 1.3 million Britons still have symptoms more than a month after catching Quid, but it can be prevented with just one application.
Dr Marie Ramsay, head of vaccines at UKHSA, said: “Vaccination is the best way to protect yourself from serious symptoms when you have an infection and can also help reduce the long-term effects.”